Team:
Matteo de Rosa, Michela Bollati, Federica Malinverno, Chiara Leonardi
Collaborators:
Luisa Diomede (Istituto di Ricerche Farmacologiche Mario Negri, Milano) Sara Pellegrino (University of Milano), Toni Giorgino (CNR-IBF) Katiuscia Pagano e Laura Ragona (CNR-SCITEC), Jan Gettemans (university of Gent), Ana Fakin (Ljubljana University Medical Centre)
The project focuses on understanding the molecular mechanisms underlying protein misfolding and aggregation associated with this rare disorder. We investigate the structural and biophysical properties of mutant gelsolin variants to elucidate how specific mutations drive amyloid formation. By combining biochemical, structural, and computational approaches, my work aims to identify key determinants of pathogenic processing. We areparticularly interested in the early steps of proteolytic cleavage and aggregation pathways. This research is carried out in close collaboration with chemists and with groups developing and studying animal models of the disease. Ultimately, this work supports the development of targeted therapeutic strategies and contributes to a broader understanding of amyloid disorders.
Fundings:
Fondazione Telethon, PRIN, amyloidosis Foundation
