Structural Basis of Cancer Signaling Networks, Cytoskeleton Remodelling and Therapeutic Targeting

Structural Basis of Cancer Signaling Networks,
Cytoskeleton Remodelling and Therapeutic Targeting

This line of research focuses on the structural and functional dissection of key protein–protein interactions regulating the NF-κB pathway, with a particular enphasis on Inhibitor of Apoptosis Proteins (IAPs).

• Targeting BIR-mediated onco-PPIs: rational design of NF-κB modulators 

• Structural TRAF2 Interactions and Therapeutic CHances  

• Gelsolin Physiopathology, cytoskeleton and related proteinopathies